Publications

Check out some of our research presentations and publications here. We are big fans of having our members at all levels gives talks, present posters, and produce scientific literature!

Click here to see our talks!

Highlighted

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells

Brian Lin, Viral S. Shah, Chaim Chernoff, Jiawei Sun, Gergana G. Shipkovenska, …, Diane E. Capen, Jorge Villoria, Zhixun Dou, Lida P. Hariri, Jayaraj Rajagopal

Nature  ·  01 May 2024  ·  doi:10.1038/s41586-024-07377-1

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

Viral S. Shah, David K. Meyerholz, Xiao Xiao Tang, Leah Reznikov, Mahmoud Abou Alaiwa, …, Paul B. McCray, Lynda S. Ostedgaard, David A. Stoltz, Christoph O. Randak, Michael J. Welsh

Science  ·  29 Jan 2016  ·  doi:10.1126/science.aad5589

All

2025

Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro

Viral S. Shah, Avinash Waghray, Brian Lin, Atharva Bhagwat, Isha Monga, …, Toni M. Delorey, Srinivas Vinod Saladi, Aviv Regev, Jayaraj Rajagopal, Alexander M. Tsankov

Nature Communications  ·  04 Jun 2025  ·  doi:10.1038/s41467-025-60441-w

The identification and characterization of hillocks in the postnatal mouse and human airway

Yohana Otto, Gergana Shipkovenska, Qiaozhen Liu, Jiawei Sun, Lida P. Hariri, Viral S. Shah, Jayaraj Rajagopal

openRxiv  ·  16 Apr 2025  ·  doi:10.1101/2025.04.15.648833

2024

The TIPping point: Inflammation and Ionocyte loss

Viral S. Shah, Jayaraj Rajagopal

Respirology  ·  19 Nov 2024  ·  doi:10.1111/resp.14857

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells

Brian Lin, Viral S. Shah, Chaim Chernoff, Jiawei Sun, Gergana G. Shipkovenska, …, Diane E. Capen, Jorge Villoria, Zhixun Dou, Lida P. Hariri, Jayaraj Rajagopal

Nature  ·  01 May 2024  ·  doi:10.1038/s41586-024-07377-1

2023

Cystic Fibrosis: “Ionocyte Modulators”?

Viral S. Shah, Jayaraj Rajagopal

American Journal of Respiratory Cell and Molecular Biology  ·  01 Sep 2023  ·  doi:10.1165/rcmb.2023-0169ED

Autofluorescence imaging permits label-free cell type assignment and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs)

Viral S Shah, Jue Hou, Vladimir Vinarsky, Jiajie Xu, Manalee V Surve, Charles P Lin, Jayaraj Rajagopal

eLife  ·  30 Mar 2023  ·  doi:10.7554/eLife.84375

2022

Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do?

Viral S. Shah, Raghu R. Chivukula, Brian Lin, Avinash Waghray, Jayaraj Rajagopal

Annual Review of Pathology: Mechanisms of Disease  ·  24 Jan 2022  ·  doi:10.1146/annurev-pathol-042420-094031

2021

Case 39-2021: A 26-Year-Old Woman with Respiratory Failure and Altered Mental Status

Aran Kadar, Viral S. Shah, Dexter P. Mendoza, Peggy S. Lai, Yasmin Aghajan, Gregory Piazza, Erica C. Camargo, Kartik Viswanathan

New England Journal of Medicine  ·  23 Dec 2021  ·  doi:10.1056/nejmcpc2107355

2016

Relationships among CFTR expression, HCO ₃ ⁻ secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies

Viral S. Shah, Sarah Ernst, Xiao Xiao Tang, Philip H. Karp, Connor P. Parker, Lynda S. Ostedgaard, Michael J. Welsh

Proceedings of the National Academy of Sciences  ·  25 Apr 2016  ·  doi:10.1073/pnas.1604905113

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

Viral S. Shah, David K. Meyerholz, Xiao Xiao Tang, Leah Reznikov, Mahmoud Abou Alaiwa, …, Paul B. McCray, Lynda S. Ostedgaard, David A. Stoltz, Christoph O. Randak, Michael J. Welsh

Science  ·  29 Jan 2016  ·  doi:10.1126/science.aad5589